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T cell surface marker detection use the T cell count, T cell subgroup classification and decision level of T cell activation,and also is an important index of the organism cellular immunity function. When the number of lymphocyte subgroup and function have an exception occurs, the body can lead to immune disorders.
(1), The significance of the total number of T cells change: CD3 molecules on the surface of all mature T cells, is an important symbol of total T cell. CD3 + T cells increased, show up in hyperthyroidism, lymphocytic thyroiditis, myasthenia gravis, and organ transplant rejection, etc. Mainly in immunodeficiency disease, malignant tumor, SEL, virus infection and used radiation therapy, chemotherapy, hormone and immune inhibitor usually with the lower index.
(2), The significance of changes of T cell subgroup:
1, For autoimmune and immunodeficiency disease: the number of CD8 + cells quantities and the function decreased is important factor of the disease, sometimes associated with an increased number and function of CD4 + cells.
The most typical example is the active systemic lupus erythematosus (SLE) patients, the percentage of CD8 + cells in peripheral blood mononuclear cells was decreased, often accompanied by increased percentage of CD4 + cells and CD4 + / CD8 + ratio increases. Other autoimmune maladies of HBsAg positive for hepatitis b, multiple sclerosis activity period , hemolytic anemia, rheumatoid disease, myasthenia gravis , acute graft versus host disease patients with have similar characteristics of T lymphocyte subsets abnormal distribution. The CD4 + / CD8 + ratio decrease is an important indication of immunodeficiency disease.
2, For kidney disease: the kidney immune response to abnormal humoral immunity. But with the research development of T lymphocyte subsets and its relationship with kidney disease is becoming more and more attention, such as with IgA nephropathy, membranous nephropathy, and nephrotic syndrome. Our test is advanced.
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