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IgA nephropathy is one kind of glomerulonephritis, which feature is IgA deposit in glomerular mesangial area. IgA nephropathy divide into primary and secondary, primary IgA nephropathy is the most common primary glomerulopathy in the world, IgA nephropathy is related to many factors, such as age, gender, race, area and so on, most of patients are young people.
IgA nephropathy is one kind of progressivity disease, only 5%~30% patients with IgA nephropathy abnormal urinalysis can be remission, most of patients is chronic progressive development. After the disease occur about 20% patients development into end stage renal disease every decade, the main development factor of IgA nephropathy is glomerulosclerosis, renal interstitial fibrosis, high blood pressure, large number of proteinuria and kidney function decrease.
At present, we still don’t know the pathogenesis of primary IgA nephropathy, the common protopathy of secondary IgA nephropathy is anaphylactoid purpura, viral hepatitis, cirrhosis, systemic lupus erythematosus, ankylosing spondylitis, chronic infectious arthritis, mixed connective tissue disease, polyarteritis nodosa, erythema nodosum, psoriasis, ulcerative colitis, crohn disease, tumour, HIV,etc
At present, we still don’t know the cause of IgA nephropathy, and no cure for the disease until now. We should slow down its progression and help protect your remaining kidney function. No matter what treatment we take, the principle of treatment is same, such as prevention and cure infection, control blood pressure, reduce proteinuria, protect kidney function, avoid overwork, and make use of dehydration and nephrotoxicity medicine, periodic review.
The common treatment include angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), glucocorticoid and other immunosuppressors, antiplatelet agglomeration, anticoagulant and fibrinolytic medicine, traditional Chinese medicine and tonsillectomy.
Traditional Chinese medicine has many forms, for IgA nephropathy, patients can take acupuncture, massage, cupping, etc, work as complementary treatments to promote blood circulation and relieve stress.
Develop good life habit
On diet, high protein diet should be avoided, it will bring extra burden to the damaged kidneys, and meanwhile, if patients appear edema, then limit salt intake is necessary, a good diet should contain low potassium, calcium, protein, phosphorus, and high in vitamin and calories.
On the other hand, patients should quit smoke and drink, smoke and drink will make the condition worse, in addition, patients should take physical activity, such as jogging, walking, cycling, and things of that sort, of course, strenuous exercise is not recommended.
In clinic, the manifestation of IgA nephropathy isolated hematuria, repeatability macroscopic haematuria, asymptomatic hematuria and proteinuria, patients also suffer edema, high blood pressure, kidney function decrease, the manifestation is nephritic syndrome or nephrotic syndrome.
1. Clinical diagnostic clues of IgA nephropathy
Although IgA nephropathy clinical manifestation and laboratory inspection lack of distinctive change, however, if people appear the following manifestation, then we should doubt whether people suffer .
When people with IgA nephropathy appear serious swelling and high blood pressure, salt should be limited less than 2g/day, even no salt diet, in general, the best is low salt diet.